PDL1 MHCII APC Cell
CBP74146
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| I. Background | |
| Programmed Cell Death Protein 1 (PD-1),一種在激活的 T 細(xì)胞上表達(dá)的受體，與其配體 PD-L1 和 PD-L2 結(jié)合，負(fù)向調(diào)節(jié)免疫反應(yīng)。 PD-1 配體存在于大多數(shù)癌癥中，PD-1:PD-L1/2 相互作用會(huì)抑制 T 細(xì)胞活性，并使癌細(xì)胞逃避免疫監(jiān)視。 PD1/PDL1信號轉(zhuǎn)導(dǎo)通路是腫瘤免疫抑制的重要組成部分，可以抑制T淋巴細(xì)胞的興奮，增強(qiáng)腫瘤細(xì)胞的免疫耐受，從而實(shí)現(xiàn)腫瘤免疫逃逸。 | |
| II. Introduction | |
| Expressed gene: | PD-L1、MHCII |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+1ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
Figure 1. RecombinantPDL1/MHCII APC Cell constitutively expressing PDL1.
Figure 2. Dose Response of Blocking Antibodies in PD-1/LAG3 Dual Effector Reporter Cells (C15) With PD-L1/MHCII APC Cells.
