Molt-4（人急性淋巴母細胞白血病細胞）
CBP60525
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| I. General information | |
| Synonyms: | Molt-4 |
| Background: | MOLT-4 was derived from the same patient as the MOLT-3 cell line (ATCC CRL-1552). The line was established from cells taken from a patient in relapse. |
| Species: | Homo sapiens, human |
| Tissue: | Blood |
| Disease: | acute lymphoblastic leukemia |
| Gender: | male,19 years |
| Morphology: | lymphoblast |
| Growth Mode: | suspension |
| DNA Profile: | Amelogenin: XY CSF1PO: 11, 12, 13 D13S317: 12, 13 D16S539: 11, 14 D5S818: 12 D7S820: 8, 10, 11 THO1: 6, 8 TPOX: 8 vWA: 17, 18 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
RPMI1640+10%FBS Molt-4完全培養基，# CBP60525M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | CD1 (49%), CD2 (35%), CD3 A (26%) B (33%) C (34%), CD4 (55%), CD5 (72%), CD6 (22%), CD7 (77%) |
| Genes Expressed: | high levels of terminal deoxynucleotidyl transferase (TdT) are produced. |
| Cellular Products: | high levels of terminal deoxynucleotidyl transferase (TdT) are produced |
| Tumor Formation: | Yes, in untreated nude mice, anti lymphocyte serum treated mice and X-irradiated mice,Ref |
| Comments: | The patient had received prior multidrug chemotherapy. There is a G -> A mutation at codon 248 of the p53 gene. P53 is not expressed. The cells do not produce immunoglobulin or Epstein-Barr virus. The line was originally contaminated with mycoplasma but has been cured with antibiotics. For more information, please contact Cobioer (4008-750-250). |
