tTMB-P6(8.98) Reference Standard

CBP80001-6

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I. Background

Tumor mutational burden (TMB) shows great promise as a biomarker for immuno-oncology (I-O) therapy response, but progress is hindered by the lack of a standardized TMB measurement by targeted NGS panels, and an absence of TMB reference materials.

Sample ID	Cat.No.	Background	Assay	Comments
DC198N0167	CBP80001-6N	B lymphoblast, Female	500x WES	Same individual
DC198N0166	CBP80001-6T	Breast Cancer, Female	500x WES	Same individual
IDT xGenExome Research Panel v1.0捕獲，Target Region 39M, Probe Region 51M, CDS Region 33.52M; HiSeq X-TEN，af選擇0.02 cut off，再過(guò)濾。 DC198N0166 is 100% Tumor sample.

	Cut off =2%	Cut off =3%	Cut off =4%	Cut off =5%
Mutation Number	301	275	259	254
TMB value	8.98	8.20	7.73	7.58

計算數據下載：DC198N0166.tmb

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tTMB-P6(8.98) Reference Standard